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CL 218872

CAS No. 66548-69-4

CL 218872 ( —— )

Catalog No. M22192 CAS No. 66548-69-4

CL 218872 is a benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CL 218872
  • Note
    Research use only, not for human use.
  • Brief Description
    CL 218872 is a benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively).
  • Description
    CL 218872 is a benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    GABAA
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    66548-69-4
  • Formula Weight
    278.23
  • Molecular Formula
    C13H9F3N4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:13.9 mg/mL (50 mM; Need ultrasonic)
  • SMILES
    Cc1nnc2ccc(nn12)-c1cccc(c1)C(F)(F)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wang B , Lv K , Liu H , et al. Contribution of the α5 GABAA receptor to the discriminative stimulus effects of propofol in rat[J]. Neuroreport, 2018:347-352.
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